JMIRx Bio

Cholesterol biosynthesis is a critical pathway in cellular metabolism, with 3- hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) catalyzing its committed step. The inhibition of HMGR has been widely explored as a therapeutic target for managing hypercholesterolemia, and statins are the most commonly used competitive inhibitors. However, the search for novel, natural inhibitors of HMGR is still a vital area of research, especially in light of the adverse effects of the prolonged use of statins. Cochlospermum planchonii and Cochlospermum tinctorium are medicinal plants traditionally used in West Africa to treat metabolic disorders, including dyslipidemia, but the specific bioactive compounds responsible for these effects are currently poorly characterized.

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This is a peer-review report related to MS ID#69542.

This is a peer-review report related to MS ID#69542.

This is the author’s responses to peer-review reports related to MS ID#69542.

Ticks are well-known ectoparasites of domestic animals, causing significant economic losses and playing a crucial role in the transmission of pathogens within the livestock industry worldwide, including in Iran. Understanding the distribution and diversity of ticks is essential for effective control strategies, especially in regions like Tehran province, where livestock plays a vital role in the economy.

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This is the authors’ response to peer-review reports related to MS ID#68519.

The neural control of food intake involves interactions between homeostatic and nonhomeostatic systems. The nucleus accumbens shell (AcbSh) and ventral pallidum (VP) play key roles in regulating ingestive behavior and project to each other. Previous studies have shown that these projections influence food consumption, with sex differences reported in the modulation of sucrose intake by VP projections.