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The paper mentions a large-scale genetic conversion leading to high homozygosity in single-nucleotide polymorphism (SNP) genotypes. What are the potential implications of this genetic conversion on the behavior and stability of the cell line, particularly in terms of its use in vaccine production and biotechnological applications?
Response: In general, the change in SNP genotype may alter the amino acid sequence (nonsynonmous SNP) or may not cause a change in the amino acid sequence (synonymous SNP).
JMIRx Bio 2024;2:e62911
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The paper mentions a large-scale genetic conversion leading to high homozygosity in single-nucleotide polymorphism genotypes. What are the potential implications of this genetic conversion on the behavior and stability of the cell line, particularly in terms of its use in vaccine production and biotechnological applications?
4. How was the FOH-SA cell line authenticated at the European Collection of Authenticated Cell Cultures?
JMIRx Bio 2024;2:e62905
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Association between the VDR and CYP24 A1 polymorphisms and atopic dermatitis.
a SNP: single-nucleotide polymorphism.
b OR: odds ratio.
c P value (comparison with the null model).
d P value for the null model.
e Statistically significant (P
Association between the VDR and CYP24 A1 polymorphisms and the severity of atopic dermatitis, asthma, rhinitis, and asthma+rhinitis.a
a P value is shown for each group. Atopic dermatitis severity is based on Scoring Atopic Dermatitis (SCORAD).
JMIR Dermatol 2023;6:e39567
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Global Melanoma Correlations With Obesity, Smoking, and Alcohol Consumption
Among them, alcohol consumption showed the strongest positive correlation with both melanoma incidence (R=0.72; P
To understand how genetic risk factors have a role in the observed correlation between alcohol consumption and melanoma incidence/mortality, we examined the correlation of aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism with both alcohol consumption and melanoma outcomes. ALDH2 is an alcohol-metabolizing enzyme, and its allelic variation affects alcohol detoxification [4].
JMIR Dermatol 2021;4(2):e31275
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