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I would have liked to understand the reason behind carrying out motility assays at 25 °C when the worms were maintained at 20 °C. Is it because it is ideal?
3. It could be that I might have read it wrong, but to me, the labels in Figures 1, 2, and S2 seem to be off. They don’t match the alphabetical order, or I might be missing something here.
4.
JMIRx Bio 2024;2:e60571
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Based on the data from Figure 4, the authors conclude that downregulation of pgrn-1 or flp has minimal or no effect on motility during adulthood under DR conditions. Overall, the findings indicate that though there is increased translation of pgrn-1 or flp genes upon DR, these genes do not function as DR effectors.
Hence, a more appropriate title would be “Progranulin and FRamides do not play a role in DR-related longevity and proteostasis.”
JMIRx Bio 2024;2:e60570
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