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This is a peer-review report submitted for the paper “Effects of Ventral Pallidum–Nucleus Accumbens Shell Neural Pathway Modulation on Sucrose Consumption and Motivation in Female Rats: Chemogenetic Manipulation Study.”
The manuscript from Peroutka and Covelo [
1. Why were only female rats used for this study?
2. What was the approximate age of the rats at the start of the study?
3. The conclusion of the pathway being relevant for sucrose consumption but not food motivation is reasonable, but it would be stronger if the comparisons were made with sucrose consumption versus sucrose motivation and also food consumption versus food motivation.
4. Are there more objective data from analysis of the immunohistochemistry? What is presented are representative images, but was there any quantification done?
5. The authors discuss cell types but do not specify the likely type of neurons stimulated in this study; is it possible to do so?
The authors have addressed my concerns from the initial draft.
None declared.