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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIRxBio</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIRx Bio</journal-id>
      <journal-title>JMIRx Bio</journal-title>
      <issn pub-type="epub">2819-2044</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v2i1e58903</article-id>
      <article-id pub-id-type="pmid"/>
      <article-id pub-id-type="doi">10.2196/58903</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Peer-Review Report</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Peer-Review Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Peer Review of “Establishing Antimicrobial Resistance Surveillance in the Water and Environment Sector in a Resource-Limited Setting: Methodical Qualitative and Quantitative Description of Uganda’s Experience From 2021 to 2023”</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Leung</surname>
            <given-names>Tiffany</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Mboowa</surname>
            <given-names>Gerald</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8445-9414</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Makerere University</institution>
        <addr-line>Kampala</addr-line>
        <country>Uganda</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Gerald Mboowa <email>gmboowa@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2024</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>7</day>
        <month>5</month>
        <year>2024</year>
      </pub-date>
      <volume>2</volume>
      <elocation-id>e58903</elocation-id>
      <history>
        <date date-type="received">
          <day>27</day>
          <month>3</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>27</day>
          <month>3</month>
          <year>2024</year>
        </date>
      </history>
      <copyright-statement>©Gerald Mboowa. Originally published in JMIRx Bio (https://bio.jmirx.org), 07.05.2024.</copyright-statement>
      <copyright-year>2024</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Bio, is properly cited. The complete bibliographic information, a link to the original publication on https://bio.jmirx.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://bio.jmirx.org/2024/1/e58903" xlink:type="simple"/>
      <related-article related-article-type="companion" id="preprint50588" ext-link-type="doi" xlink:href="https://doi.org/10.2196/preprints.50588" vol="1" page="e50588" xlink:title="Preprint:" xlink:type="simple">https://preprints.jmir.org/preprint/50588</related-article>
      <related-article related-article-type="companion" id="v2i1e58949" ext-link-type="doi" xlink:href="10.2196/58949" vol="2" page="e58949" xlink:title="Authors' Response to Peer-Review Reports:" xlink:type="simple">https://bio.jmirx.org/2024/1/e58949/</related-article>
      <related-article related-article-type="companion" id="v2i1e50588" ext-link-type="doi" xlink:href="10.2196/50588" vol="2" page="e50588" xlink:title="Published Article:" xlink:type="simple">https://bio.jmirx.org/2024/1/e50588/</related-article>
      <kwd-group>
        <kwd>antimicrobial resistance</kwd>
        <kwd>surveillance system</kwd>
        <kwd>water and environment sector</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>
      <italic>This is a peer-review report submitted for the paper “Establishing Antimicrobial Resistance Surveillance in the Water and Environment Sector in a Resource-Limited Setting: Methodical Qualitative and Quantitative Description of Uganda’s Experience From 2021 to 2023”</italic>
    </p>
    <sec>
      <title>Round 1 Review</title>
      <sec>
        <title>General Comments</title>
        <p>This paper [<xref ref-type="bibr" rid="ref1">1</xref>] is timely and presents data on antimicrobial resistance (AMR) surveillance in the water and environment sector in a resource-limited setting.</p>
      </sec>
      <sec>
        <title>Specific Comments</title>
        <sec>
          <title>Methodology</title>
          <p>“A stepwise approach was employed. Governance structures were streamlined and sector-specific AMR surveillance guiding documents developed” -&gt; “were developed”</p>
          <p>“Conslusion” -&gt; Check the spelling.</p>
          <p>“CONFLICTS OF INTEREST” -&gt; “CONFLICT OF INTEREST”</p>
        </sec>
        <sec>
          <title>Antimicrobial Resistance Governance Establishment and Enhancement</title>
          <p>“To streamline the AMR governance in the water and environment sector, a sector-specific AMR technical working group (TWG) was instituted with identified a focal person to coordinate the surveillance activities in the sector.” (Rewrite this.)</p>
        </sec>
      </sec>
      <sec>
        <title>Major Comments</title>
        <sec>
          <title>Enhancement of the Microbiology Capacity of the National Water Quality Reference Laboratory</title>
          <p>I would like to see a description of the testing platforms in this lab and plans for genomic surveillance of AMR since it reveals more about the complexity, evolution, and transmission of these pathogens as seen here.</p>
        </sec>
      </sec>
      <sec>
        <title>Minor Comments</title>
        <sec>
          <title>AMR Data Generation</title>
          <p>“The developed sector-specific AMR surveillance documents were pretested.” (How was this done?”)</p>
        </sec>
      </sec>
      <sec>
        <title>Discussion</title>
        <p>Figure 1: It would be important to share this data via a public dashboard like here [<xref ref-type="bibr" rid="ref2">2</xref>]. “Liguori et al. have described the methods as fairly standardized, and an avenue for further analysis of the recovered isolates including sensitivity testing, sequence-based typing and whole genome sequencing, which aid in detecting and identifying antibiotic-resistant genes and genetic elements [<xref ref-type="bibr" rid="ref3">3</xref>].” And virulence factors [<xref ref-type="bibr" rid="ref4">4</xref>].</p>
        <p>Authors should also discuss making a sentence on the contribution of environmental wastewater sequencing.</p>
        <p>As a way forward, I wish to request the authors set up a public dashboard to share this important AMR surveillance data to stakeholders beyond the TWG as seen here [<xref ref-type="bibr" rid="ref5">5</xref>].</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group/>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AMR</term>
          <def>
            <p>antimicrobial resistance</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">TWG</term>
          <def>
            <p>technical working group</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
      <fn fn-type="other">
        <p><bold>Editorial notice</bold>: A peer reviewer conflict of interest was identified prior to publication: They work at the same institution or organization as an author. They have published with an author during the past 5 years.</p>
      </fn>
    </fn-group>
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</article>
